Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
نویسندگان
چکیده
منابع مشابه
Chitosan-based polyelectrolyte complexes for drug delivery
Among different polymers, chitosan, the N-deacetylated product of the polysaccharide chitin, is gaining increasing importance in medical and pharmaceutical applications due to its good mucoadhesion and absorption enhancing ability. Moreover, chitosan shows the ability to form hydrogels able to control the rate of drug release from the delivery system as well as protect the drug from chemical an...
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Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysaccharide in modified release dosage forms for oral administration is its fast d...
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The objective of this investigation was the development of chitosan/xanthan polyelectrolyte complex based mucoadhesive nasal insert of promethazine hydrochloride a drug used in the treatment of motion sickness. A 32 factorial design was applied for preparing chitosan/xanthan polyelectrolyte complex and to study the effect of independent variables i.e. concentration of xanthan [X1] and concentra...
متن کاملLyophilized chitosan/xanthan polyelectrolyte complex based mucoadhesive inserts for nasal delivery of promethazine hydrochloride
The objective of this investigation was the development of chitosan/xanthan polyelectrolyte complex based mucoadhesive nasal insert of promethazine hydrochloride a drug used in the treatment of motion sickness. A 32 factorial design was applied for preparing chitosan/xanthan polyelectrolyte complex and to study the effect of independent variables i.e. concentration of xanthan [X1] and concentra...
متن کاملChitosan-based Drug Delivery Systems
The most important characteristics of chitosans, which make them useful as delivery vectors for drugs and therapeutic proteins, are their excellent mucoadhesive and absorption enhancing properties [1-3]. The mucoadhesion is due to the electrostatic interaction between the positive charge on the chitosan polymer and the negatively charged sialic acid residues on the mucosal surface [4]. Because ...
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ژورنال
عنوان ژورنال: Journal of Membrane Science
سال: 2008
ISSN: 0376-7388
DOI: 10.1016/j.memsci.2008.04.011